Isorhamnetin (IRN) Attenuates Cognitive Dysfunction Induced by the Intracerebroventricular Injection of Amyloid beta 25-35 (Aβ 25-35) in Sprague Dawley rats

Amyloid beta (Aβ 25-35) is reported to induce oxidative stress in the brain and there are growing evidences of its possible play in Alzheimer’s disease. The exact cause and pathogenesis of neurodegenerative diseases is not certain but oxidative stress, excitotoxicity and neuroinflammation play important role in its pathogenesis. Dietary intake of antioxidant rich food and fruits has been shown to benefit, delay, prevent and treat many aging related disorders, inflammatory diseases. Bioflavonoid, Isorhamnetin has strong antioxidant and anti-inflammatory properties. Therefore, the present study was conducted to check the neuroprotective effect of Isorhamnetin (IRN) against Aβ induced neurobehavioral changes. Intracerebroventricular injection of Aβ 25-35 caused learning and memory deficits as assessed by Radial arm maze (RAM), Morris water maze (MWM). It has also showed impairment in visual recognition memory and exploratory activity in Novel object recognition test and open field test respectively. Treatment with IRN (25mg/kg b.wt.) reduced all the behavioral abnormalities significantly than the IRN 50 mg/kg b.wt. treated rats. Our finding concluded that Isorhamnetin has potent neuroprotective effect against Amyloid beta induced neurotoxicity in rat.